How To Unlock All Characters In The Binding Of Isaac. It would be an understatement to say that The Binding Of Isaac is a complex game. Furthermore, the game has grown in depth over time thanks to a number of well-received DLCs. Secret levels and hidden challenges abound, but they’re nearly impossible to locate without the help of a guide.
The playable characters one area where the game is well-balanced. Several are quite simple to unlock, and even a novice player can do so with some effort, while others are only accessible to those who have completely mastered the game’s limitations. That isn’t even taking into account the tainted versions of each character, which must unlocked individually.
Russ Boswell updated this page on February 27th, 2022: The Binding of Isaac is unquestionably one of the most fascinating, exciting, and in-depth Indie releases ever. What began as a simple game quickly grew in popularity, prompting the creator to produce a slew of DLC. With the release of Repentance marking the conclusion of The Binding of Isaac, now is a fantastic moment to dive into the game for the first time and play through the complete adventure from beginning to end. There are numerous objects and characters to discover, some of which are quite tough to obtain. This Binding of Isaac character unlock guide updated with fresh information to further assist gamers in obtaining new characters.
Table of Contents
Magdalene
- HP: 4 x Full Red Hearts
- Damage: 3.5
- Range: 6.5
- Speed: 0.85
Magdalene is likely the first character players will acquire, and she designed for newcomers who require assistance in the early hours of the game. She starts with four hearts instead of the customary three, and she also carries a Yum Heart item to help her regain her health. She also has no notable drawbacks other than a slightly slower mobility speed.
It’s not difficult to unlock Magdalene, but it will need some luck. To access Magdalene, players must have seven heart containers at the same time. There are a lot of objects that grant more heart containers, and they’re very prevalent on the early floors, so players should have no issue getting here.
Cain
- HP: 2 x Full Red Hearts
- Damage: 4.2
- Range: 4.5
- Speed: 1.3
Cain deals slightly more damage at the outset than Isaac and has an item that boosts his luck. This comes at a cost, since Cain only has two heart containers to begin with.
The method for unlocking Cain is also simple, although it does necessitate a consistent amount of luck over the course of a run. Cain may only unlocked by holding 55 coins at once. Because this is rare to happen organically in a run, players’ best bet is to try their luck at the slot machines if they come across one.
Judas
- HP: 1 x Full Red Heart
- Damage: 4.72
- Range: 6.5
- Speed: 1.0
Judas begins with the item “Book of Belial,” which means “wicked or worthless.” Judas has a lot of basic damage, which the book helps with. He does, however, begin with only one heart container.
Judas is the first character who requires some effort to unlock. To unlock Judas, players must vanquish Satan. Sheol, the secret floor, is where Satan can be located. At the conclusion of Womb II, there is a door that leads to this floor. A Devil Door will appear after conquering Mom’s Heart, but always after fighting It Lives, housing the trapdoor that leads to Sheol.
???
- HP: 3 x Full Soul Hearts
- Damage: 3.67
- Range: 6.5
- Speed: 1.1
???, also known as “Blue Baby” by the fanbase, a dark character who thought to a deceased version of Isaac. ??? has somewhat improved damage and speed, but their most notable trait is that they begin with no heart containers and instead use Soul Hearts. It goes much further than that, as??? will never be able to obtain heart containers. As a result,??? is a character for people seeking a challenge.
??? Unlocking is straightforward, but it will need some work, since players must defeat Mom’s Heart ten times, effectively completing the game 11 times.
Eve
- 2 × Full Red Hearts HP
- 2.62 damage (growing to 3.5 with 1 x Full Heart remaining).
- 6.5 to 6.5
- 1.23 miles per hour
Eve is a character with a surprising amount of strength. With reduced damage and two heart containers, she may not appear to be it at first glance. She does, however, begin with an outstanding equipment that increases her damage and speed while she is on one red heart or less. She also Dead Bird, which summons a familiar to deal damage to adversaries when she hurt.
To access Eve, players must complete a task in which they must not pick up any hearts for two levels in a row, implying that they must be exceedingly cautious of their damage.
Samson
- 3 × Full Red Hearts HP
- 3.5 points for damage
- Speed: 1.1 Range: 5.0
Samson given the Bloody Lust item at the start of the game, which doubles his damage output everytime he takes damage. His fire rate is modest, but his three heart containers provide players with a lot of strategic options.
Samson, like Eve, unlocked by completing a challenge in which players must not take any damage for two consecutive floors. It’s one of the more difficult challenges for a character to complete, although experienced players should be able to complete it in a few tries throughout the first two floors.
Azazel
- HP: 3 x Full Black Hearts
- Damage: 5.5
- Range: 4.5
- Speed: 1.25
Azazel is a very powerful character in the hands of those who know how to use him properly. Azazel unleashes an energy beam at his opponents instead of tears, which delivers a lot of damage. He also has the ability to fly and begins with The Fool card, which allows him to teleport to the beginning of a floor once. The disadvantage is that the beam isn’t very long, so Azazel will have to come near to his foes to kill them, and he doesn’t have any heart containers to begin with, instead starting with three Black Hearts.
Unlocking Azazel isn’t particularly difficult, although it does necessitate a bit of luck. Azazel can unlocked by making three bargains with the Devil in a single run. A Devil Room must spawn at least once in a run, and players must have enough heart containers to sacrifice in order to accept the deals.
Lazarus
- HP: 3 x Full Red Hearts
- Damage: 3.5
- Range: 4.5
- Speed: 1.0
Lazarus isn’t a particularly good character at first, with lower overall stats than Isaac and a random effect pill. He does, however, start with an extra life, and when he dies, he transforms into Lazarus’ Risen, who only has one heart container but improves almost every stat.
Lazarus is one of the most straightforward characters to unlock, though it will take some effort. At the same time, players must have 4 Soul Hearts or Black Hearts. Soul Hearts aren’t hard to get by, but players must cautious about how much damage take because Soul Hearts are always the first to be lost.
Eden
- HP: Random
- Damage: Random
- Range: Random
- ​​​​​​​Speed: Random
Eden is an enigmatic figure. Eden’s stats aren set in stone because everything about them (even their haircut) generated at random at the start of each run. Eden can spawn with anything from three red hearts to a single soul heart, and their stats can range from excellent to disastrous.
To get them, players must finish The Womb, which requires them to beat Mom’s Heart for the first time. Although defeating the final monster theoretically required, Eden one of the simpler characters to unlock due to the single prerequisite.
The Lost
- HP: No Health
- Damage: 3.5
- Range: 6.5
- ​​​​​​​Speed: 1.0
The Lost have the same stats as Isaac, with the exception that they do not have hearts. They have no health, not just red hearts, but any type of heart. This means that they will die instantly if they are hit by anything, and they will not able to gain any form of heart. They begin with an Eternal D6, which allows them to reroll any things they obtain.
Unlocking The Lost before the Afterbirth DLC was a long and difficult process. However, with that DLC, things became a lot easier (although still difficult). To unlock the Missing Poster item, players must die in a Sacrifice Room while carrying it. Although it appears straightforward, defeating The Lamb while playing as Isaac required to obtain the Missing Poster. The Lamb a hidden boss that can only accessed by beating Satan five times while carrying The Negative item.
Alternatively, provided the player has enough hearts, injuring himself on the spikes in a Sacrifice Room 12 times. The same floor would result in a 50% probability of teleported to the floor where The Lamb awaits. For every hit on the spikes after the 12th, this 50% probability rerolled.
Lilith
- HP: 1 x Full Red Heart, 2 x Full Black Hearts
- Damage: 3.5
- Range: 6.5
- ​​​​​​​Speed: 1.0
Lillith is the first DLC character to added to the game, and she a distinct play style. She has the Blindfolded condition for the rest of her life, which means she can’t cry. Instead, she must deal damage using her Incubus familiar. She also has Cambion Conception, which generates a new familiar after taking enough damage, and the Box of Friends, which spawns a replica of every active familiar in the current room.
To unlock Lilith, you must defeat Greed Mode while playing as Azazel. Greed Mode is a wave-based mode in which players must battle waves of monsters throughout seven different floors before facing Ultra Greed, a one-of-a-kind boss.
Keeper
- HP: 2 x Full Coin Hearts (3 x later on)
- Damage: 4.2
- Range: 6.5
- ​​​​​​​Speed: 0.85
Keeper one of the most difficult characters to unlock, both in terms of playstyle and how they’re unlocked. Coin Hearts, which only heal when coins picked up, spawn with Keeper. There are only two by default, but if you play Keeper long enough, you can unlock more. They begin with a triple shot as a bonus.
Unlocking them will take a lot of time and effort, and will once again revolve around the game’s Greed Mode. When Ultra Greed beaten at the end of each Greed Mode run, a donation machine similar to the one in the shop appears. Players can put all of their spare coins into this machine, which will gradually unlock character enhancements. To unlock Keeper, players must first increase the counter on this machine to 999, then deposit another coin to reset it to zero.
Apollyon
- HP: 2 x Full Red Hearts
- Damage: 3.5
- Range: 6.5
- ​​​​​​​Speed: 1.0
Apollyon, named after the angel known as “The Destroyer,” has a very distinct play style from the majority of the characters. His stats are exactly the same as Isaac’s. He does, however, spawn with the item The Void. Any goods on the floor, such as those in Treasure and Boss rooms, consumed by this. When you consume a passive item, you get a random stat boost, but when you consume an active item, you get the opposite benefit. When players employ The Void, all of the effects it has absorbed will activated.
Also Read: How To Craft Recipes In Elden Ring
Players must battle Mega Satan in order to unlock Apollyon. Mega Satan is located on the same floor as The Lamb, but hidden behind the giant locked golden door in the floor’s starting area. To open this door, players must combine two crucial components, both of which are difficult to open.
To unlock them, gamers must first fight The Lamb while playing as??? After that, players must obtain two Angel Rooms and beat .The Angel boss in each (the fights are started by bombing the angel statue in the centre of the room). Take the two key pieces to the Dark Room or Chest, and the door will immediately unlock, allowing you to vanquish Mega Satan and make Apollyon a playable character.
The Forgotten
- HP: 2 x Full Bone Heart (1 x Full Soul Heart as Soul)
- Damage: 3.5
- Range: 6.5
- ​​​​​​​Speed: 1.0 (1.3 as Soul)
The Forgotten is the oddest of all the available characters because it is essentially two characters in one. Players will control both The Forgotten and The Soul when playing as The Forgotten. The Forgotten deals more damage and has two Bone Hearts to begin with, which take three hits to drain, whereas The Soul just has one Soul Heart. If The Soul perishes, The Forgotten perishes as well.
This character’s unlocking is the most difficult of all (except The Lost pre-DLC), with secrets layered on top of secrets. First, kill the first floor’s boss in under a minute (a sound effect will play to signal victory). Ten proceed to the floor’s beginning room, which should obscured by the shadow of a shovel. The Broken Shovel item will appear if you bomb anywhere in the room. This item makes Mom try to stomp on the player all the time, so be careful.
Second, players must reach the Depths in under 20 minutes to defeat Mom, which unlocks the Boss Rush. If you beat the Boss Rush, you’ll receive the second piece of the Broken Shovel, creating Mom’s Shovel. Next, discover the Grave Room on the Dark Room floor, which should have a solitary patch of soil in the centre. The Forgotten will opened if you use Mom Shovel while standing in the dirt.
Bethany
- HP: 3 x Full Red Hearts
- Damage: 3.5
- Range: 6.5
- ​​​​​​​Speed: 1.0
Bethany is Lazarus’ sister and the first character from the Repentance DLC. In terms of statistics, she appears to be a very ordinary character. She has three Red Hearts and average numbers in all other areas. Can’t pick up Soul or Black Hearts, either, because they used to charge her active goods. She begins with the Book of Virtues, which is one of these items. Wisps spawn around the player, shooting tears at foes, but they can killed if they receive enough hits.
Playing as Lazarus on hard mode unlocks Bethany. Without losing a life, players must run all the way to Mom’s Heart/It Lives and defeat it. This will be a difficult task for Lazarus because he was much weaker in his previous incarnation.
Jacob & Esau
- HP: 3 x Full Red Hearts (1 x Full Red Heart, 1 x Full Soul Heart as Esau)
- Damage: 2.75 (3.75 as Esau)
- Range: 1.15 (0.85 as Esau)
- ​​​​​​​Speed: 1.0
Another duo, but one that is more powerful than The Forgotten & The Soul, is the final selectable character. Jacob has three Red Hearts, as well as above-average luck, shot speed, and fire rate. However, his damage is below-average. Esau possesses one Soul and one Red Heart, as well as below-average luck, shooting speed, and fire rate, but above-average damage. The possibilities are endless when it comes to balancing this combo with things.
Mother, one of the game’s most gruesome-looking bosses, must defeated in order to access these characters. It’s important to note that this is not the same boss as Mom, who can be located in the Depths. Getting there entails a slew of chores that must done across several runs.
To , players must obtain the achievement “A Secret Exit.” This accomplished through defeating repentance bosses like Baby Plum, Reap Creep, and The Pile. Who normal bosses found in Basement and Depths. Once that done, a locked door will appear at the end of Basement, which may opened with a key to lead players to Downpour. On one of those floors, there will be a room with a white fireplace that, when touched, will change the players into The Lost. This will allow you to enter the Mirrored World through a mirror, locate the Treasure Room, and obtain Knife Piece 1.
Second, after the conclusion of Downpour, a new door will appear that requires two bombs to open. This will transport players to Mines. A room with a minecart on a damaged track and a boarded-up door will spawn there. To fix the railway, find three yellow buttons on the floor and press them, then touch the minecart. Knife Piece 2 will found inside the room, which when combined will form Mom’s Knife.
Third, near the conclusion of Mines, there will be a door that requires two hearts to open (The Lost can enter for free). This is the entrance to the Mausoleum. When you reach the bottom of this floor and fight Mom, a meaty door will appear. It will open if you stab it with the knife. Inside, players must beat Mom’s Heart to get access to a room containing the Corpse entrance.
Finally, go to the end of Corpse and start fighting the Mother. Prepared for a multi-stage confrontation, and overcoming her will unlock Jacob and Esau.
Tainted Characters
The “Tainted” mechanic introduced with the release of Repentance, which added alternate versions of all 17 characters. These unlockable forms improved versions of the original character designs, marked by minor (or major, in the case of Isaac) sprite modifications. Characters with a tainted past have a unique set of mechanics, which frequently taken to extremes.
Players must get the Red Key during a run and use it on a Hidden closet in the Home level to unlock a Tainted version of a character. Doing so on a certain character will unlock the tainted form of that character, meaning players will have to do so 17 times to gather them all.